• Dear Guest, if you are new here please "sign up" at the top if you'd like to post messages. And if you have used this forum before note we upgraded to new forum software and couldn't transfer the passwords. To get into your account, click on the "log in" button, then click on "Forgot your password?" and reset your password. All previous posts were safely transferred to the new system but custom avatars and private messages unfortunately didn't get moved over. The upside is a newer, simpler, friendly forum.

receptor downregulation with long-term use

Hi all,

I'm new to this forum. I have some wonderful results with St John's Wort. However, I noticed that it stopped working between 1 and 2 months of taking it regularly. I know this is due to receptors in the brain becoming desensitized or down-regulating. I took a 4 day break, started taking St John's again, and voila, it's working again! Does anyone have any experience with this? I have read that some people take a one week break every month to curb the down-regulation. I would obviously like to manage this as efficiently as possible so that I can feel good as often as possible! I would appreciate any insights/experiences any of you have to offer. Also any dosing schedules that you have had success or failures with. Thank you!