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Does SJW increase dopamine?

Discussion in 'General discussion on depression and SJW' started by Cinderella108, Jan 19, 2012.

  1. Cinderella108

    Cinderella108 Regular Member

    I would like to know if this is the case, because as a prolactinoma patient I have low dopamin levels and normally as a medicine Dostinex or Cabergoline are the usual solution. In October 2011 I discontinued with Dostinex because of the strong side effects and I have started with SJW, first with 900 dosage. My blood results in november were very good, my prolactin level was almost normal, low as never before.
    4 weeks ago I have decreased SJW on 300 and my new blood results from last week had shown that my prolactin level again increased ( from 44 up to 62).
    So now I'm wondering if SJW maybe increased my dopamin levels and as result my prolactin level was almost normal, but after my reduction of the dosage prolactin is raising again.
    What do you think?
     
  2. sheephead

    sheephead Moderator

    Cinderella,

    I think there may be a link between SJW and increased dopamine levels. My depression was characterised by sluggishness, grogginess, poor cognitive function and feeling withdrawn. Having researched the subject, these symptoms seem to be associated more with low dopamine levels than serotonin. Low serotonin tends to accompany anxiety and raised emotional states (crying etc.). SJW remedied my 'low dopamine' symptoms like the flick of a switch. Within 3-4 days of starting Kira in 2002 my symptoms were 90% improved. I have always had a strong (although entirely unscientific) hunch that one of SJW's main strengths is that it re-balances low dopamine levels.

    Sheephead.
     
  3. Cinderella108

    Cinderella108 Regular Member


    My symptoms were similar to yours, but I also had anxiety. After 5 or 6 weeks on SJW they were strong improved, so there must have been something between SJW and dopamine. I hope I will soon feel the improvement again, I'm back on 600 mg daily.

    Cindy
     
  4. DaneV

    DaneV New Member

    Yes SJW increases dopamine levels in the prefrontal cortex, at least in rats.
    If this is relevant to it`s mechanism of action is still unknown.
     
  5. Cinderella108

    Cinderella108 Regular Member

  6. shadowking

    shadowking New Member

    Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.

    Franklin M, Chi J, McGavin C, Hockney R, Reed A, Campling G, Whale RW, Cowen PJ.

    University Department of Psychiatry, Warneford Hospital, Oxford, UK.

    BACKGROUND: We studied the effect of a single dose of a formulation of a methanolic extract of Hypericum perforatum (HP), also known as St. John's wort, on plasma concentrations of growth hormone (GH), prolactin (PRL), and cortisol (CORT) in 12 healthy male volunteers. METHODS: Subjects received 9 tablets of the finished product Jarsin 300 and placebo in a double-blind, balanced-order, cross-over design. RESULTS: Following HP relative to placebo, there was a significant increase in plasma GH and a significant decrease in plasma PRL. Plasma CORT levels were unchanged. CONCLUSIONS: Taken together with data from animal experimental studies, the findings suggest that this dose of HP may increase some aspects of brain dopamine function in humans.


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    J Psychopharmacol 2000;14(4):360-3 Related Articles, Links


    Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat.

    Franklin M, Chi JD, Mannel M, Cowen PJ.

    University Department of Psychiatry, Warneford Hospital, Oxford, UK. michael.franklin@psych.ox.ac.uk

    Extracts of Hypericum perforatum (St John's wort), such as LI 160, which are effective antidepressants have several active constituents. Their mode of action in depression, however, is unclear. In the present investigation, we assessed the effect of equivalent doses of LI 160 and two of its components, hypericin and hyperforin on serotonin (5-HT) and dopamine (DA)-mediated neuroendocrine responses in the rat. LI 160, hypericin and hyperforin significantly and equivalently increased plasma corticosterone. This effect was blocked by ketanserin but not WAY-100635, suggesting mediation via 5-HT2 receptors. LI 160 also lowered plasma prolactin and prevented the increase in plasma prolactin following haloperidol administration. Hyperforin had a similar but somewhat less pronounced effect. We conclude that LI 160, hypericin and hyperforin all increase 5-HT-mediated corticosterone release while LI 160 enhances DA-mediated inhibition of prolactin release. Hyperforin may contribute to the facilitatory effect of LI 160 on DA function, but hypericin does not.

    -----------------------------

    Pharmacopsychiatry 2001 Jul;34 Suppl 1:S29-37 Related Articles, Links


    Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.

    Franklin M, Cowen PJ.

    University of Oxford Department of Psychiatry, Warneford Hospital, UK.

    We have studied the effect of acute and sub-chronic treatments of a formulation of a methanolic extract of hypericum perforatum (HP, also known as St John's wort) on plasma hormones and brain neurotransmitters in healthy human volunteers and rats. Also studied were the effects of equivalent acute doses of two constituents of HP (with respect to LI 160 extract), hypericin and hyperforin in rats. In acute treatment studies in normal volunteers subjects received 9 tablets of the finished product Jarsin 300 and placebo in the pilot study (unblinded) and in the main study (a double blind, balanced order, cross-over design). Results in normal volunteer studies show that HP caused significant increases of salivary cortisol and plasma growth hormone (GH) whereas it decreased plasma prolactin versus placebo. Plasma hormone levels were associated with a rise in plasma hyperforin but not with hypericin, however no significant correlation was found. In the animal studies, acute treatment with LI 160, hyperforin and hypericin all caused significant increases in plasma corticosterone. This was associated with significant increases in brain cortical tissue 5-HT content. The corticosterone responses were attenuated by the 5-HT2 receptor antagonist, ketanserin but not by the 5-HT1A antagonist, WAY-100635. This suggests that the corticosterone responses may be mediated via a 5-HT2 mechanism of action. When sub-chronic and acute treatment using two different doses of LI 160 were compared, plasma corticosterone level were significantly decreased. Thus suggesting a down-regulation or desensitisation of post-synaptic 5-HT2 receptors. Plasma prolactin was significantly reduced by acute treatment with LI 160 and hyperforin treatment but not by hypericin. This was associated with a concomitant rise in brain cortical tissue DA. Both LI 160 and hyperforin treatments decreased the plasma prolactin responses to the DA antagonist, haloperidol, suggesting that this may be associated with a DA-mediated mechanisn of action. When acute and sub-chronic treatments were compared, plasma prolactin responses were increased in the sub-chronically treated animals. The studies when taken together suggest that the LI 160 extract may effect plasma hormonal changes via both 5-HT and DA-mediated mechanisms but do not involve noradrenaline (NA). The data also suggests that hyperforin may be more important than hypericin for effecting these changes following acute treatment. Further studies investigating both acute and sub-chronic effects of these compounds are necessary.
     
  7. Marina 2110

    Marina 2110 New Member

    Hello Cinderella,

    I saw that you are also a prolactinoma patient and using SJW.
    How is it going now after 5 years?

    For me it is the same situation.

    Regards,
    Marina
     

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