Hi, I am new to this forum, and I have taken St Johns Before (years ago) And I was taking it at night before bed(900mg) and taking a centrum vitamin(at same time) for about 1 1/2 weeks It was working great at first(though I was dizzy alot and kinda slow to articulate, and process thought at times) Then I noticed i was becoming irritable and was fighting with people alot and I actually got so mad later on that i repeatedly hit my couch(smart enough not to break my hand or valuables ) I was more pissed than i have been in over a year! I have had psychological problems in the past , and drug use (weed, alcool, opiates, Dextromethorphan, Meth, Coke, shrooms) Though that was 2 years ago. I was hospitalized twice in an 8 month period in late 2003 for psychosis and delusions brought on by Recreational Dextromethorphan, and Ephreda(sudafed) use in conjunction with weed and alcohol, and benzos, and pain killers, THE WORKS!! I was VERY suicidal so.. But I am kind of getting irrated because I will take a drug to help when I am depressed or manic(bipolor i would say i have) and it will work for a period of 2 wekks or less then i have to stop taking it and i start feeling fine again after i'm off of it. then a few weeks, or less later i am back to depressed and manic all over again!! I have tried literally EVERYTHING heres a b rief list: 5-HTP, SJW, Paxil(never again, tremors!) Prozac(sexual side effects, and homicidal ideations!) Wellbutrin(sexual, and hallucinations, delusions, rage) Lexapro(worked somewhat when i took it might still but my insurance doesnt cover) Abilify(increased psychosis, suicidal plotting) Zyprexa(worst ever!) Seroquel(works a little when i am literally holding a knife to my throat, but doesnt really help otherwise, cuz it makes you idle as hell!!) Taken others too pretty much all the major anti-psycotics, and anti-depressants I have at one time or another taken! I am not really suicidal anymore so thats not the issue I just have mood swings, and go from mania to depression easily and it really effects my life, so if anyone has any advice or any links or anything please help me I'm begging you!!